Pd-Catalyzed [2 + 2 + 2] Cyclization of Alkyne-cyclohexadienones and <i>O</i>-Akynyl Benzenesulfonamides for Construction of Fused Tricyclic Hydronaphthofurans
A palladium-catalyzed [2 + 2 + 2] cyclization of 1,6-enynes with unsymmetrical alkynes has been successfully accomplished, resulting in the formation of a series of fused tricyclic hydronaphthofurans with high stereo- and regioselectivity in a single step. This reaction demonstrates 100% atomic economy and exhibits a broad substrate scope.
Authors
- Junbiao Chang (ORCID: https://orcid.org/0000-0001-6236-1256)
- Miaomiao Tian (ORCID: https://orcid.org/0000-0001-9443-6857)
- Bingxian Liu (ORCID: https://orcid.org/0000-0001-9872-9876)
- Xuxu Ma
- Tianyun Zhang
Institutions
- Henan Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1021/acs.joc.4c02447
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province
- National Key Research and Development Program of China
- Central Plains Scholars and Scientists Studio Fund