Hydrogenation of Sugar Enol-Ethers Using Pd/Et<sub>3</sub>SiH Reagent System: A Route to Deoxy Sugars/Glycosides
We have developed a hydrogenation method using Pd(OAc)<sub>2</sub>/Et<sub>3</sub>SiH as a reagent system for sugar enol ethers and their glycosides. This approach is highly effective and applicable to a wide range of glycals and glycosides, achieving yields up to 96% for the corresponding deoxy sugars. Applying standard conditions to various O/C-glycosides resulted in excellent transformation to 2,3-dideoxy glycosides.
Authors
- Ram Pratap Pandey
- Nazar Hussain (ORCID: https://orcid.org/0000-0003-4387-3971)
- Bindu Tiwari
Institutions
- Institute of Medical Sciences (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1021/acs.joc.4c02031
- Citations
- 2
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Banaras Hindu University
- Science and Engineering Research Board