Inflammation and hemostasis in loiasis before and after ivermectin treatment: A biological pilot cross-sectional study

We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densities (p<0.001 and p = 0.044, respectively). At day 4 following ivermectin administration, median eosinophils rose from 171/μL to 1,095/μL (p<0.001) and median D-dimers increased from 582 ng/mL to 745 ng/mL (p = 0.024) with a median relative variation of +34.7%. C-reactive protein, fibrinogen, and alpha-1-globulin also increased significantly after treatment. Ivermectin treatment appeared to induce inflammation, coagulation activation and fibrinolysis.

Authors

Institutions

Publication Details

Journal
PLoS neglected tropical diseases
Published
2024-12-16
DOI
https://doi.org/10.1371/journal.pntd.0012491
Primary Topic
Parasitic Diseases Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Inflammation and hemostasis in loiasis before and after ivermectin treatment: A biological pilot cross-sectional study

Jérémy T. Campillo, Claude Tagny Tayou, Tristan M. Lepage, Narcisse Nzune-Toche et al.
PLoS neglected tropical diseases
Parasitic Diseases Research and Treatment
article

Inflammation and hemostasis in loiasis before and after ivermectin treatment: A biological pilot cross-sectional study

Jérémy T. Campillo, Claude Tagny Tayou, Tristan M. Lepage, Narcisse Nzune-Toche, Hugues C. Nana-Djeunga, Charlotte Boullé, Cédric B. Chesnais, Michel Boussinesq, Sébastien D. S. Pion, Lucie A. Nkwengoua, Joseph Kamgno
article en

Abstract

We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densities (p<0.001 and p = 0.044, respectively). At day 4 following ivermectin administration, median eosinophils rose from 171/μL to 1,095/μL (p<0.001) and median D-dimers increased from 582 ng/mL to 745 ng/mL (p = 0.024) with a median relative variation of +34.7%. C-reactive protein, fibrinogen, and alpha-1-globulin also increased significantly after treatment. Ivermectin treatment appeared to induce inflammation, coagulation activation and fibrinolysis.

PLoS neglected tropical diseasesVol. 18(12)
Université de Yaoundé I (CM), Inserm (FR), Université de Montpellier (FR), Centre Hospitalier Universitaire de Montpellier (FR), Ministry of Scientific Research and Innovation (CM), University Teaching Hospital of Yaounde (CM), Institut de Recherche pour le Développement (FR)
European Commission, H2020 European Research Council
Good health and well-being
Openalex Percentile: Top 71%
Parasitic Diseases Research and Treatment
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.