Caffeine Therapy for Apnea of Prematurity: Single-Center Study on Dosing Practices and Perceived Effectiveness
This study highlights the frequent use of higher caffeine dosages in clinical practice than registered and recommended based on long-term safety data. Despite these high dosages and frequent mini-loads, 28% of patients still required additional treatment with doxapram and/or invasive mechanical ventilation, indicating the need for individualized dosing strategies or alternative therapies.
Authors
- Gerard J. Hutten (ORCID: https://orcid.org/0000-0003-4368-6519)
- Irwin Reiss (ORCID: https://orcid.org/0000-0002-9474-6895)
- Robert B. Flint (ORCID: https://orcid.org/0000-0002-3658-594X)
- Kelly K. Storm (ORCID: https://orcid.org/0009-0008-4199-3797)
- Sinno H. P. Simons (ORCID: https://orcid.org/0000-0001-5219-5696)
- Anton H. van Kaam (ORCID: https://orcid.org/0000-0003-4030-7085)
- Wes Onland
Institutions
- Erasmus MC (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Neonatology
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1159/000543074
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84