Single-cell RNA sequencing via endoscopic ultrasound-guided fine-needle biopsy for pancreatic tumors uncovered an aggressive subclone with a poor prognosis
EUS-FNB with a negative pressure of 5 ml is feasible for scRNA-seq in clinical practice. A UBE2C high-expression subclone correlates with a poor prognosis, potentially becoming a new therapeutic target in future studies.
Authors
- Chuan‐Ming Yeh (ORCID: https://orcid.org/0000-0001-8456-0125)
- Yee Chao (ORCID: https://orcid.org/0000-0001-5578-340X)
- Yun Su (ORCID: https://orcid.org/0000-0003-4397-3278)
- Yan‐Shen Shan (ORCID: https://orcid.org/0000-0002-2457-5189)
- Yi‐Cheng Hou (ORCID: https://orcid.org/0000-0002-8114-166X)
- Yi‐Sheng Liu (ORCID: https://orcid.org/0000-0002-1085-1947)
- Daw‐Yang Hwang (ORCID: https://orcid.org/0000-0002-5139-3612)
- Sheng-Jen Cheng (ORCID: https://orcid.org/0000-0001-5993-1473)
- Chien‐Jui Huang (ORCID: https://orcid.org/0000-0002-5503-9266)
- Meng Lin (ORCID: https://orcid.org/0000-0003-4095-0820)
- Li‐Tzong Chen (ORCID: https://orcid.org/0000-0003-3250-7167)
- Chun‐Wei Hsu (ORCID: https://orcid.org/0009-0002-2142-7647)
- Chih‐Teng Yu
- W.-L. Chang
Institutions
- Kaohsiung Medical University (TW)
- National Health Research Institutes (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1016/j.esmogo.2024.100113
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- Kaohsiung Medical University
- National Health Research Institutes
- National Science and Technology Council