Current opportunities for the prevention and treatment of carbohydrate metabolism disorders

Diabetes mellitus poses a significant threat to the health and lives of people worldwide. Consequently, the timely identification of individuals at risk and the prevention of disease development are of utmost importance. Increasing physical activity, reducing body weight, and quitting smoking are effective measures for preventing type 2 diabetes. When lifestyle modifications are insufficient, pharmacological glucose-lowering therapy is prescribed. The endocrinologist’s arsenal is dominated by drugs that have a predominant effect on hyperglycemia. Metformin is the 1st line of therapy for disorders of carbohydrate metabolism. It is known that insulin resistance is the main cause of the development and progression of complications of diabetes mellitus. Correction of insulin resistance looks like a promising drug tactic. However, the choice of a drug for these purposes is currently limited. Currently, new, promising drugs are being developed that can increase tissue sensitivity to insulin. Subetta is an original insulin sensitizer that helps to enhance insulin-dependent glucose metabolism. This is a complex drug that increases the sensitivity of tissues to insulin, and normalizes the function of the vascular endothelium, as well as helps to increase the level of adiponectin. A decrease in glycemic parameters, a reduction of the insulin resistance index (HOMA-index) and weight stabilization has been shown in the clinical studies. All-Russian observational non-interventional study is planned to assess the effectiveness of Subetta in real-world clinical practice for patients with prediabetes or type 2 diabetes (SILA). The study includes data from 2,500 patients approximately over the age of 18. The findings of this programme enable a comprehensive evaluation of the effectiveness of combined glucose-lowering therapy in conjunction with Subetta, based on the dynamic assessment of both clinical and laboratory parameters, as well as quality of life questionnaires.