HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma
IHC stratification of primary tumors by HMGA2 and GATA6 statuses in pancreatic cancer is associated with differential outcomes, survival following chemotherapy, and tumor microenvironments. As a nuclear marker for basal disease, HMGA2 complements GATA6 to identify disease subtypes in PDAC.
Authors
- Kiran Vij (ORCID: https://orcid.org/0000-0003-3633-0565)
- Marianna B. Ruzinova (ORCID: https://orcid.org/0000-0002-0833-8335)
- Jacqueline L. Mudd (ORCID: https://orcid.org/0000-0001-7618-8765)
- Sunil R. Hingorani (ORCID: https://orcid.org/0000-0002-3869-8729)
- Miki Haraguchi
- Nina G. Steele (ORCID: https://orcid.org/0000-0003-1564-3562)
- E. Gabriela Chiorean
- Annie N. Samraj
- Sita Kugel (ORCID: https://orcid.org/0000-0001-7202-187X)
- Naomi Yamamoto (ORCID: https://orcid.org/0000-0002-0641-6547)
- Liang‐I Kang (ORCID: https://orcid.org/0000-0001-7025-3095)
- Stephanie Dobersch (ORCID: https://orcid.org/0000-0002-6633-4228)
- Howard C. Crawford (ORCID: https://orcid.org/0000-0001-9360-3019)
- Rachael A. Safyan (ORCID: https://orcid.org/0000-0002-0181-6007)
- Ian M. Loveless (ORCID: https://orcid.org/0000-0003-4645-6559)
- Faiyaz Notta (ORCID: https://orcid.org/0000-0002-5748-3985)
- David G. DeNardo (ORCID: https://orcid.org/0000-0002-3655-5783)
- Thomas Walsh (ORCID: https://orcid.org/0009-0007-5435-2561)
- Ryan C. Fields (ORCID: https://orcid.org/0000-0001-6176-8943)
- Gun Ho Jang (ORCID: https://orcid.org/0000-0001-8169-7011)
- Li Li (ORCID: https://orcid.org/0000-0003-4841-2330)
- Nathan M. Bolton (ORCID: https://orcid.org/0000-0002-7275-6005)
Institutions
- Ontario Institute for Cancer Research (CA)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Ochsner Health System (US)
- Henry Ford Health System (US)
- University of Toronto (CA)
- Wayne State University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Ochsner Medical Center (US)
- Princess Margaret Cancer Centre (CA)
- Henry Ford Hospital (US)
- Fred Hutch Cancer Center (US)
- Cancer Consortium (US)
- Research Canada (CA)
- University of Nebraska Medical Center (US)
- Michigan State University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2200
- Citations
- 8
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.26