Isothiocyanates induce autophagy and inhibit protein synthesis in primary cells via modulation of AMPK-mTORC1-S6K1 signaling pathway, and protect against mutant huntingtin aggregation
Our study showed that ITCs induce autophagy and inhibit protein synthesis in both primary mesenchymal and cancer cells via modulation of the AMPK-mTORC1-S6K1 pathway. Moreover, it suggests that ITCs might have a potential in developing therapeutics for Huntington's disease.
Authors
- Joanna Brokowska (ORCID: https://orcid.org/0000-0003-3620-4200)
- Aleksandra Hać (ORCID: https://orcid.org/0000-0002-0478-3263)
- Anna Herman-Antosiewicz (ORCID: https://orcid.org/0000-0003-0526-2168)
Institutions
- University of Gdańsk (PL)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1007/s00394-024-03539-z
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.55