The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer
This biomarker study explored HER2 expression levels and immune cell characteristics that may affect response to T-DXd using tumor tissue samples collected from clinical trial participants. The results suggest that HER2 expression levels and tumor characteristics before the initiation of T-DXd may correlate with the efficacy of the drug.
Authors
- Makito Koga (ORCID: https://orcid.org/0009-0005-0318-4727)
- Kohei Shitara (ORCID: https://orcid.org/0000-0001-5196-3630)
- Hiroyoshi Nishikawa (ORCID: https://orcid.org/0000-0001-6563-9807)
- Hiroki Goto (ORCID: https://orcid.org/0000-0002-6884-6841)
- Shohei Koyama (ORCID: https://orcid.org/0000-0002-6897-9417)
- Naoya Wada (ORCID: https://orcid.org/0000-0002-3903-6815)
- Yosuke Togashi (ORCID: https://orcid.org/0000-0001-9910-0164)
- Yusuke Kuwahara (ORCID: https://orcid.org/0009-0000-2912-7273)
- Maki Kobayashi (ORCID: https://orcid.org/0000-0001-5920-5906)
- Fumitaka Suto (ORCID: https://orcid.org/0009-0009-5649-2650)
- Akihito Kawazoe (ORCID: https://orcid.org/0000-0001-8632-3748)
- Shigehiro Koganemaru (ORCID: https://orcid.org/0000-0003-1323-4896)
- Takeo Arita
- Tomoko Shibutani (ORCID: https://orcid.org/0000-0002-6991-6610)
- Tohru Okabayashi
- Tsuyoshi Hirata
- Kenji Nakamaru
- Koichiro Inaki
Institutions
- Okayama University (JP)
- Daiichi Sankyo (Germany) (DE)
- Osaka City University (JP)
- National Cancer Centre Japan (JP)
- Daiichi-Sankyo (Japan) (JP)
- Chiba Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Daiichi Sankyo (United States) (US)
- National Cancer Research Institute (GB)
- Nagoya University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0302
- Citations
- 6
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- AstraZeneca
- Astellas Pharma
- Ono Pharmaceutical
- Daiichi Sankyo Europe