Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator
While numbers in the current RCT were small and require further validation in larger cohorts, the results nevertheless suggest a molecular mechanism by which maternal folic acid supplementation during pregnancy may help to counteract the effects of folate depletion and positively influence cognitive development in the offspring.
Authors
- Mary Ward (ORCID: https://orcid.org/0000-0001-6470-1728)
- Michelle Clements
- Aoife Caffrey (ORCID: https://orcid.org/0000-0002-7991-7262)
- Kristina Pentieva (ORCID: https://orcid.org/0000-0003-2059-534X)
- L Hilman
- Miroslava Ondičová (ORCID: https://orcid.org/0000-0002-9033-7373)
- Colin Conway
- Colum P. Walsh (ORCID: https://orcid.org/0000-0001-9921-7506)
- Rachelle E Irwin (ORCID: https://orcid.org/0000-0002-6137-1716)
- Helene McNulty (ORCID: https://orcid.org/0000-0002-4366-6457)
Institutions
- Linköping University (SE)
- University of Ulster (GB)
- University of British Columbia (CA)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1186/s12916-024-03804-2
- Citations
- 2
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Linköpings Universitet
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council