Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene
Relapse of L. infantum infection after applying allopurinol for 1316 days due to resistance was suspected clinically. Positive PCR testing, consistent hematological and biochemistry abnormalities, and reduction in the METK gene CN backed up the clinical suspicion of resistance. Dogs infected with allopurinol resistant strains of L. infantum may represent a great risk for infection of naïve dogs, cats, and humans.
Authors
- Mathieu Faucher
- Alexandra Kehl (ORCID: https://orcid.org/0000-0002-1547-0713)
- Ingo Schäfer (ORCID: https://orcid.org/0000-0001-9264-6607)
- Gad Baneth (ORCID: https://orcid.org/0000-0002-7549-1305)
- Yaarit Nachum‐Biala (ORCID: https://orcid.org/0000-0001-7336-4698)
- Torsten J. Naucke
- Elisabeth Müller (ORCID: https://orcid.org/0000-0002-0686-9503)
- Lluís Ferrer (ORCID: https://orcid.org/0000-0003-1537-0074)
- Marina Carrasco (ORCID: https://orcid.org/0000-0001-8301-8000)
Institutions
- Hebrew University of Jerusalem (IL)
- Laboklin (Germany) (DE)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1186/s13071-024-06583-0
- Citations
- 7
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.80