Deeply Implantable, Shape‐Morphing, 3D MicroLEDs for Pancreatic Cancer Therapy
Controlled photooxidation-mediated disruption of collagens in the tumor microenvironment can reduce desmoplasia and enhance immune responsiveness. However, achieving effective light delivery to solid tumors, particularly those with dynamic volumetric changes like pancreatic ductal adenocarcinoma (PDAC), remains challenging and limits the repeated and sustained photoactivation of drugs. Here, 3D, shape-morphing, implantable photonic devices (IPDs) are introduced that enable tumor-specific and continuous light irradiation for effective metronomic photodynamic therapy (mPDT). This IPD adheres seamlessly to the surface of orthotopic PDAC tumors, mitigating issues related to mechanical mismatch, delamination, and internal lesions. In freely moving mouse models, mPDT using the IPD with close adhesion significantly reduces desmoplastic tumor volume without causing cytotoxic effects in healthy tissues. These promising in vivo results underscore the potential of an adaptable and unidirectional IPD design in precisely targeting cancerous organs, suggesting a meaningful advance in light-based therapeutic technologies.
Authors
- Seyong Oh (ORCID: https://orcid.org/0000-0002-3989-1117)
- Enlai Yang
- Dong Yeol Hyeon
- Jae Hee Lee
- Myoung Song (ORCID: https://orcid.org/0000-0002-5249-8176)
- Taek‐Soo Kim (ORCID: https://orcid.org/0000-0002-2825-7778)
- Haohui Zhang (ORCID: https://orcid.org/0000-0001-8432-3672)
- Tae‐Hyuk Kwon (ORCID: https://orcid.org/0000-0002-1633-6065)
- Chae Gyu Lee (ORCID: https://orcid.org/0000-0002-7887-5312)
- Keon Jae Lee (ORCID: https://orcid.org/0000-0001-7500-3079)
- Seungyeob Kim (ORCID: https://orcid.org/0000-0001-7375-4821)
- Young-Hoon Jung (ORCID: https://orcid.org/0000-0001-9509-9186)
- Daniel J. Joe (ORCID: https://orcid.org/0000-0002-1945-8236)
- Yoon Hee Kwon
- Sanghun Jeon (ORCID: https://orcid.org/0000-0002-1146-5968)
- Yoon Ji Choi (ORCID: https://orcid.org/0000-0002-0856-6012)
- Yonggang Huang (ORCID: https://orcid.org/0000-0001-9899-8590)
- Min Seo Kim (ORCID: https://orcid.org/0009-0005-1877-6522)
Institutions
- Northwestern University (US)
- Korea Advanced Institute of Science and Technology (KR)
- Korea Research Institute of Standards and Science (KR)
- Hanyang University (KR)
- Ulsan National Institute of Science and Technology (KR)
- Massachusetts Institute of Technology (US)
- Anyang University (KR)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1002/adma.202411494
- Citations
- 9
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.66
Funders
- National Research Foundation of Korea