Total synthesis of the taraxacine A natural product <i>via</i> Ag(<scp>i</scp>)-catalysed imidate-alkyne cyclization
A domino approach towards β-carboline natural product taraxacine A and its analogues was developed. The main step relies on a silver(I) and base co-catalysed imidate-alkyne cyclization. The reaction tolerates primary and secondary alcohols, and various substitutions in the indole are possible.
Authors
- Rajesh R. Zalte (ORCID: https://orcid.org/0000-0003-0679-2312)
- Alexandra S. Golubenkova (ORCID: https://orcid.org/0000-0002-2991-6325)
- Никита Е. Голанцов (ORCID: https://orcid.org/0000-0002-4897-5398)
- Alexey А. Festa (ORCID: https://orcid.org/0000-0002-5113-1938)
- Leonid G. Voskressensky (ORCID: https://orcid.org/0000-0002-9676-5846)
- Olga А. Storozhenko (ORCID: https://orcid.org/0000-0003-1489-7683)
- Anton P. Novikov (ORCID: https://orcid.org/0000-0001-5430-0955)
- Sergei A Demidov
- Samuel O Awuku (ORCID: https://orcid.org/0000-0002-4522-5794)
- Yuri Yu Mironov
Institutions
- Peoples' Friendship University of Russia (RU)
- Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences (RU)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1039/d4ob01876a
- Citations
- 1
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.23