Non-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro–Nanochip for Isolating Fetal Nucleated Red Blood Cells
This novel chip not only enables efficient enrichment of fNRBCs for NIPD but also extends the diagnostic window for genetic and developmental disorders to as early as 7 weeks of gestation, potentially allowing for earlier interventions. By improving the accuracy and reliability of NIPD, this technology could reduce reliance on invasive diagnostic techniques, offering a new pathway for diagnosing fetal genetic conditions in clinical practice.
Authors
- Xingzhong Zhao
- Naiqi Li
- Chun Feng (ORCID: https://orcid.org/0000-0002-0938-7331)
- Lin Cheng (ORCID: https://orcid.org/0000-0002-0020-4404)
- Saisai Yang
- Yuqi Shao (ORCID: https://orcid.org/0009-0002-2716-9888)
- Yuanzhen Zhang (ORCID: https://orcid.org/0000-0003-4832-7902)
- Yifan Sun (ORCID: https://orcid.org/0000-0003-4484-7599)
- Yue Sun (ORCID: https://orcid.org/0000-0002-0134-5401)
Institutions
- Xinyang Normal University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Children's Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/ijn.s479297
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University