CEP signaling coordinates plant immunity with nitrogen status
Plant endogenous signaling peptides shape growth, development and adaptations to biotic and abiotic stress. Here, we identify C-TERMINALLY ENCODED PEPTIDEs (CEPs) as immune-modulatory phytocytokines in Arabidopsis thaliana. Our data reveals that CEPs induce immune outputs and are required to mount resistance against the leaf-infecting bacterial pathogen Pseudomonas syringae pv. tomato. We show that effective immunity requires CEP perception by tissue-specific CEP RECEPTOR 1 (CEPR1) and CEPR2. Moreover, we identify the related RECEPTOR-LIKE KINASE 7 (RLK7) as a CEP4-specific CEP receptor contributing to CEP-mediated immunity, suggesting a complex interplay of multiple CEP ligands and receptors in different tissues during biotic stress. CEPs have a known role in the regulation of root growth and systemic nitrogen (N)-demand signaling. We provide evidence that CEPs and their receptors promote immunity in an N status-dependent manner, suggesting a previously unknown molecular crosstalk between plant nutrition and cell surface immunity. We propose that CEPs and their receptors are central regulators for the adaptation of biotic stress responses to plant-available resources.
Authors
- Julia Santiago (ORCID: https://orcid.org/0000-0002-5765-6495)
- Henriette Leicher
- Ralph Hückelhoven (ORCID: https://orcid.org/0000-0001-5632-5451)
- Martin Stegmann (ORCID: https://orcid.org/0000-0002-7168-5970)
- Jakub Rzemieniewski (ORCID: https://orcid.org/0000-0001-7274-383X)
- Christian Wiese (ORCID: https://orcid.org/0000-0002-9473-7411)
- Vilde Olsson Lalun (ORCID: https://orcid.org/0000-0002-0453-7062)
- A. Corina Vlot (ORCID: https://orcid.org/0000-0002-8146-6018)
- Julian Maroschek (ORCID: https://orcid.org/0000-0003-2451-050X)
- Caroline Broyart (ORCID: https://orcid.org/0000-0003-3436-637X)
- Michael A. Djordjevic (ORCID: https://orcid.org/0000-0002-9819-1372)
- Zeynep Camgöz
- Shahran Nayem
- Hyun Kyung Lee (ORCID: https://orcid.org/0000-0001-5295-1834)
Institutions
- Australian National University (AU)
- University of Oslo (NO)
- Helmholtz Zentrum München (DE)
- Institute of Botany (AM)
- University of Bayreuth (DE)
- Technical University of Munich (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1038/s41467-024-55194-x
- Citations
- 24
- Primary Topic
- Plant-Microbe Interactions and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 14.39
Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Norges Forskningsråd
- Technische Universität München
- Université de Lausanne