White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis
This study demonstrated a causal relationship between mtDNA-CN and SA, with specific brain white matter microstructure phenotypes potentially acting as mediators. These findings highlight the potential of mtDNA-CN as a biomarker for SA and underscore its relevance in guiding future therapeutic strategies targeting mitochondrial health and brain white matter microstructure.
Authors
- M Y Wang (ORCID: https://orcid.org/0009-0008-1827-2158)
- Xinyi Huang (ORCID: https://orcid.org/0000-0003-1771-474X)
- Changyun Sun (ORCID: https://orcid.org/0000-0002-5715-2705)
- Jie Guo (ORCID: https://orcid.org/0000-0001-7473-1015)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-3453-3257)
- Zichen Zhao (ORCID: https://orcid.org/0000-0003-1861-1208)
- Qiaohui Ying (ORCID: https://orcid.org/0009-0009-1787-8251)
- Yongwei Wu (ORCID: https://orcid.org/0000-0002-6651-7032)
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Provincial Hospital (CN)
- Jinan Stomatological Hospital (CN)
Publication Details
- Journal
- Nature and Science of Sleep
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/nss.s487782
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- European Bioinformatics Institute
- Gujarat Council on Science and Technology
- National Natural Science Foundation of China