Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy
These may become biomarkers for incident DSPN, guide prevention strategies and serve as proof of concept for the utility of IMML in studying complex diseases.
Authors
- Barbara Thorand (ORCID: https://orcid.org/0000-0002-8416-6440)
- Wolfgang Rathmann (ORCID: https://orcid.org/0000-0001-7804-1740)
- Michael Roden (ORCID: https://orcid.org/0000-0001-8200-6382)
- Karsten Suhre (ORCID: https://orcid.org/0000-0001-9638-3912)
- Dániel Garger (ORCID: https://orcid.org/0000-0002-0544-3383)
- Holger Prokisch (ORCID: https://orcid.org/0000-0003-2379-6286)
- Michael P. Menden (ORCID: https://orcid.org/0000-0003-0267-5792)
- Jerzy Adamski (ORCID: https://orcid.org/0000-0001-9259-0199)
- Haïfa Maalmi (ORCID: https://orcid.org/0000-0002-2910-1142)
- Gabi Kastenmüller (ORCID: https://orcid.org/0000-0002-2368-7322)
- Diyuan Lu (ORCID: https://orcid.org/0000-0002-9525-4251)
- Gidon J. Bönhof (ORCID: https://orcid.org/0000-0003-1446-6592)
- Christian Herder (ORCID: https://orcid.org/0000-0002-2050-093X)
- Harald Grallert
- Mélanie Waldenberger (ORCID: https://orcid.org/0000-0003-0583-5093)
- Christian Gieger (ORCID: https://orcid.org/0000-0001-6986-9554)
- Phong Nguyen (ORCID: https://orcid.org/0000-0002-0882-6208)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Dan Ziegler (ORCID: https://orcid.org/0000-0001-8956-3552)
Institutions
- University of Ljubljana (SI)
- The University of Melbourne (AU)
- National University of Singapore (SG)
- Zimmer Biomet (Netherlands) (NL)
- Helmholtz Zentrum München (DE)
- Düsseldorf University Hospital (DE)
- Institute of Bioinformatics and Systems Biology (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Weill Cornell Medical College in Qatar (QA)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1038/s43856-024-00637-1
- Citations
- 1
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Helmholtz Zentrum München