Sanggenol L Alleviates Rotenone-induced Parkinson's Disease and Inhibits Mitochondrial Complex I by Apoptosis Via P13K/AKT/mTOR Signalling
Our findings indicate that SL showed protective effects against rotenone-induced OS, mitochondrial complex-I in neuronal cell damage, which suggests that SL might potentially serve as an anti-PD remedial candidate for PD treatment.
Authors
- Menghai Wu
- Annamalai Vijayalakshmi
- Periyannan Velu (ORCID: https://orcid.org/0000-0003-3894-9556)
- Jianbin Zhang (ORCID: https://orcid.org/0000-0002-5601-8547)
- Nan Zhao (ORCID: https://orcid.org/0000-0001-7740-5186)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shenyang 242 Hospital (CN)
- Jinan City People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2024-12-13
- DOI
- https://doi.org/10.2174/0113862073358649241128053921
- Citations
- 4
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.94