Targeting Breast Cancer: Novel Dihydropyrimidinones As Potent Eg5 Inhibitors
Compound 3j fits well at the allosteric site of Eg5 protein 1QOB. Compound 3j emerged as the most cytotoxic, displaying significant and impressive growth inhibitory activity (GI<sub>50</sub>=24.08 μM).
Authors
- Dhirajkumar Nikam (ORCID: https://orcid.org/0000-0002-6418-4991)
- Shweta Jadhav
- Shraddha Vetale
- Anurekha Jain
- Ashwini Bhange
Institutions
- Devi Ahilya Vishwavidyalaya (IN)
- Bharati Vidyapeeth (Deemed to be University) (IN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2024-12-16
- DOI
- https://doi.org/10.2174/0115734064336338241112043509
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00