Targeted APT8(16–34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells
We have identified APT8 (16- 34), which exhibits specific targeting and internalization capabilities into activated hepatic stellate cells. Moreover, when conjugated with miR-23b-5p, APT8 (16-34) also internalizes into activated hepatic stellate cells, enabling miR-23b-5p exert their respective functions.
Authors
- Jiangfeng Wu (ORCID: https://orcid.org/0000-0002-4717-0141)
- Siyuan Wu (ORCID: https://orcid.org/0000-0002-9041-8587)
- Yanqiong Zhang (ORCID: https://orcid.org/0000-0002-9358-111X)
- Yi‐Ran Ni (ORCID: https://orcid.org/0000-0002-4298-3231)
- Cheng Jiang (ORCID: https://orcid.org/0000-0003-1730-8581)
- Botao Li (ORCID: https://orcid.org/0000-0001-5487-9231)
- Ruitao Zhang (ORCID: https://orcid.org/0000-0001-5610-9433)
- Lu Huang (ORCID: https://orcid.org/0000-0002-1064-7399)
- Hongbing Zhang (ORCID: https://orcid.org/0000-0001-6291-1027)
- Jiaojiao Wang (ORCID: https://orcid.org/0000-0002-6624-8717)
- Xue Yang (ORCID: https://orcid.org/0000-0003-1965-0399)
- Lan Ma (ORCID: https://orcid.org/0000-0001-7797-1436)
- Liqing Yang (ORCID: https://orcid.org/0000-0003-4444-559X)
- Ling Huang (ORCID: https://orcid.org/0000-0002-5173-689X)
- Ying Wang (ORCID: https://orcid.org/0009-0003-8907-5614)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-7853-979X)
- Xiaolian Wang (ORCID: https://orcid.org/0009-0007-1158-0871)
Institutions
- China Three Gorges University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jiangxi Pingxiang People's Hospital (CN)
Publication Details
- Journal
- Hepatology International
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1007/s12072-024-10760-9
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- National Natural Science Foundation of China