PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder
In summary, these data show that PLAP is expressed in a significant fraction of pT2-4 urothelial carcinomas, unrelated to cancer aggressiveness but associated with specific molecular features. Once anti-PLAP cancer drugs become effective, urothelial carcinoma is a candidate tumor entity for clinical evaluation.
Authors
- Thorsten Schlomm (ORCID: https://orcid.org/0000-0001-9557-4653)
- Maximilian Lennartz (ORCID: https://orcid.org/0000-0002-1572-8200)
- Guido Sauter (ORCID: https://orcid.org/0000-0002-9024-4978)
- Krystian Kaczmarek (ORCID: https://orcid.org/0000-0002-4898-960X)
- Tobias Klatte (ORCID: https://orcid.org/0000-0002-4392-6861)
- Henrik Samtleben
- Nico Adamini
- Sebastian Hofbauer (ORCID: https://orcid.org/0000-0002-1796-9905)
- Michael Rink
- Sarah Weinberger (ORCID: https://orcid.org/0000-0002-4259-8990)
- Joachim Weischenfeldt (ORCID: https://orcid.org/0000-0002-3917-5524)
- Kira Furlano (ORCID: https://orcid.org/0000-0003-1724-7061)
- Simon Schallenberg (ORCID: https://orcid.org/0000-0002-7897-7116)
- Sarah Jane Pauline Minner (ORCID: https://orcid.org/0000-0003-0765-3568)
- Stefan Koch (ORCID: https://orcid.org/0000-0003-3579-4229)
- Sefer Elezkurtaj (ORCID: https://orcid.org/0000-0002-1699-1270)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Marcin Słojewski (ORCID: https://orcid.org/0000-0003-3679-7325)
- Thorsten Ecke (ORCID: https://orcid.org/0000-0002-0787-2763)
- Henning Plage (ORCID: https://orcid.org/0000-0002-7680-1870)
- Henrik Zecha
- Florian Roßner (ORCID: https://orcid.org/0000-0003-1763-765X)
- Ronald Simon (ORCID: https://orcid.org/0000-0003-0158-4258)
- Martina Kluth (ORCID: https://orcid.org/0000-0003-4782-4616)
- Andreas Holger Marx (ORCID: https://orcid.org/0000-0002-5182-8364)
- Margit Fisch
Institutions
- University of Copenhagen (DK)
- Universität Hamburg (DE)
- Rigshospitalet (DK)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Helios Hospital Bad Saarow (DE)
- Albertinen Diakoniewerk (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Klinikum Fulda (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- International Urology and Nephrology
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1007/s11255-024-04319-8
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Charité – Universitätsmedizin Berlin
- Deutsche Gesellschaft für Urologie