Knockdown of Methylation‐Related Gene <scp>MBD2</scp> Blocks Cell Growth by Upregulating p21 Expression in Head and Neck Squamous Cell Carcinoma
These results indicated that shRNA-mediated MBD2 knockdown suppresses HNSCC cell growth by upregulating p21 expression. In addition to its role as an oncogene, MBD2 may serve as a prognostic biomarker and therapeutic target for HNSCC patients.
Authors
- Ting Cao (ORCID: https://orcid.org/0000-0002-5436-6724)
- Fei Pei
- Jun Zhang (ORCID: https://orcid.org/0000-0001-7030-2686)
- Ting Jiang (ORCID: https://orcid.org/0009-0000-9929-3429)
- Hong Zhou (ORCID: https://orcid.org/0000-0002-1484-500X)
- Xia Shen (ORCID: https://orcid.org/0000-0002-3711-2028)
Institutions
- University of Shanghai for Science and Technology (CN)
- Fudan University (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- Cancer Reports
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/cnr2.70080
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University