Novel isatin conjugates endowed with analgesic and anti-inflammatory properties: design, synthesis and biological evaluation
Compound <b>4c</b> emerged as a promising lead candidate for developing safer and more effective anti-inflammatory and analgesic agents. Its robust efficacy, safety profile, and computational validation highlight its potential for further optimization in therapeutic applications.
Authors
- LaVauria D. Brown (ORCID: https://orcid.org/0009-0007-2213-0104)
- Siva Sankar Panda (ORCID: https://orcid.org/0000-0003-3668-104X)
- Rajnish Kumar (ORCID: https://orcid.org/0000-0002-7021-6996)
- Rajeev Sakhuja (ORCID: https://orcid.org/0000-0002-9284-9137)
- Nermin Samir (ORCID: https://orcid.org/0000-0002-8654-5540)
- Jade T. Moore
- S. Patel (ORCID: https://orcid.org/0000-0002-2628-8036)
- Adel S. Girgis (ORCID: https://orcid.org/0000-0003-4407-9745)
- Mona F. Said
- Anurag T. K. Baidya
- Anshuman Khadanga
Institutions
- Ain Shams University (EG)
- Georgia Institute of Technology (US)
- Cairo University (EG)
- Augusta University (US)
- Augusta University Health (US)
- Lakeside Labs (AT)
- National Research Centre (EG)
- Institut Teknologi dan Sains Mandala
- Indian Institute of Technology Indore (IN)
- Birla Institute of Technology and Science, Pilani (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1080/17568919.2024.2437981
- Citations
- 6
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Augusta University