Phosphocholine inhibits proliferation and reduces stemness of endometrial cancer cells by downregulating mTOR-c-Myc signaling
PC accumulation impairs the proliferation ability and stem cell characteristics of EC cells by inhibiting the activated mTOR-c-Myc axis, potentially offering a promising strategy to enhance the efficacy of EC clinical therapy through the promotion of PC accumulation in tumor cells.
Authors
- Kun Shi (ORCID: https://orcid.org/0000-0002-9183-1306)
- Tiansong Zhang (ORCID: https://orcid.org/0009-0000-8126-9308)
- Kunxiang Gong
- Lirong Guo (ORCID: https://orcid.org/0000-0002-4956-4953)
- Weiwei Chen (ORCID: https://orcid.org/0000-0001-7681-3962)
- Yun Chen (ORCID: https://orcid.org/0000-0002-2516-0946)
- Wenjie Liu (ORCID: https://orcid.org/0000-0002-8044-5338)
- Jingyao Wang (ORCID: https://orcid.org/0000-0003-1932-1931)
- Tao Fang (ORCID: https://orcid.org/0000-0002-5085-2450)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-2611-2070)
- Yaqiong Liu
- Yanqin Zheng
- Yiming Song (ORCID: https://orcid.org/0009-0009-7229-4056)
- Feifei Pan
Institutions
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1007/s00018-024-05517-4
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province