Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, with systemic symptoms such as fever being uncommon. Adult-onset Still’s disease (AOSD) is an autoinflammatory condition characterized by high-gra

Background: Adenoid cystic carcinoma is one of the most common malignant neoplasms of salivary glands, characterized by aggressive behavior, recurrence, metastasis to distant organs, and relative radio resistance, rendering local control challenging to achieve. Objective: The goal of this work is to shed light on the role of c-KIT in the pathogenesis of salivary adenoid cystic carcinoma at the gene and protein levels. Materials and Methods: c-KIT protein expression and gene levels were determined by real-time immunohistochemistry (IHC) and polymerase chain reaction (PCR) in a total of fifty-two specimens of salivary adenoid cystic carcinoma. Results: The immunoreactivity for c-KIT antibody was observed among all of the studied cases, whereas, thirteen cases tested for c-KIT gene mutations by DNA sequencing showed no detection of genetic mutation despite being positive for immunohistochemistry. Conclusion: Although c-KIT immunopositivity is high in salivary adenoid cystic carcinoma, the absence of gene mutation renders target therapy ineffective.