Ameliorative Potential Effect Of Ethanolic Extract From Leaves Of Lanata Camara L In A Rotenone-Induced Parkinson's Disease Model In Wistar Albino Rats

Parkinsonism is a neurodegenerative disorder that primarily affects the dopaminergic neurons in the substantia nigra region of the brain. This condition is characterized by a range of motor symptoms, including tremors, bradykinesia (slowness of movement), rigidity, and postural instability. In stark contrast, animals subjected to Ethanol Leaf Extract of Lantana Camara L (ELLC), administered in both low and high doses, exhibit an intriguing augmentation in muscular rigidity and locomotor activity. ELLC treatment reduced the level of neuro-inflammation and increased the level of various anti-oxidant enzymes like SOD, CAT, MDA, Nitrite in group IV & V. It also increased activity muscular rigidity, activity and memory improvement. The study reveals the therapeutic potential of ELLC against retenone induced behavioral and neuropathological deficits in wistar albino rats. The primary aim of this investigation is to assess the capacity of ELLC in promoting remyelination and neuroprotection in animals treated with retenone, a model exhibiting notable demyelination and neurodegeneration reminiscent of Parkinson's disease. To gauge the effectiveness of ELLC, the well-established Parkinson's disease treatment, Levodopa + Carbidopa, serves as the standard drug. Remarkably, ELLC at a high dose (400 mg/kg) demonstrates effects comparable to the standard drug. Nevertheless, further research is imperative to delve deeper into the comprehensive potential of ELLC and unravel the intricate molecular pathways governing its actions. These insights are crucial for advancing our understanding of the compound's therapeutic applications and facilitating its potential translation into clinical contexts for the benefit of individuals grappling with neurodegenerative disorders.