Assessment of disease progression in children with nephrotic syndrome using atherogenic indicators

Background The nephrotic syndrome (NS) raises the risk of atherosclerosis and endothelial dysfunction. Endothelial dysfunction was measured and linked with dyslipidemia and inflammatory markers in individuals with nephrotic syndrome. LDL-cholesterol, total cholesterol, and fibrinogen are the most critical variables implicated in endothelial dysfunction in the nephrotic syndrome. Objective The study’s goal was to evaluate atherogenic indicators as markers that can be utilized to determine both atherogenic potential and cardio metabolic health. Materials and methods This study was designed as a case-control study, A total of 52 participants age range (9-12) year with nephrotic syndrome. Sample collection Collected from Kerbala pediatric teaching hospital, Iraq. Serum lipid panel (Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL) and triglycerides (TG), renal function test (blood urea and creatinine) albumin in serum and urine were all measured for the study groups. Results and conclusion The results of the study showed a massive increasing in the mean levels of the atherogenic indices in (NS) patients compared to the control group. Diagnostic thresholds point of the atherogenic indices were indicated that most of the measured indices shown a highly sensitivity and specificity toward the lipid complication in (NS) case. In our point of view, theses indices provided novel clues on the atherogenic mechanisms in such cases, which might reflect the inflammatory signals more effectively than lipid panel.