Quorum sensing inhibitor: an effective strategy to attenuate the virulence and drug resistance of <i>Pseudomonas aeruginosa</i>

<i>Pseudomonas aeruginosa</i> is a significant contributor to food spoilage and foodborne diseases. The primary strategy for preventing and controlling contamination by <i>P. aeruginosa</i> involves the application of antibacterial agents. However, the overuse or abuse of antimicrobial agents has accelerated the development of drug resistance. The control of spoilage and antimicrobial resistance in <i>P. aeruginosa</i> has emerged as a major food safety challenge. Numerous studies have established that the pathogenicity and drug resistance of <i>P. aeruginosa</i> are regulated by quorum sensing (QS). Therefore, inhibiting the QS system of <i>P. aeruginosa</i> is a promising approach to mitigate the pathogenicity and resistance of this pathogen. This review explores various QS systems of <i>P. aeruginosa</i> and their roles in bacterial pathogenesis and drug resistance. Additionally, it discusses the potential of small chemical molecules and quorum-quenching enzymes in attenuating the pathogenesis of <i>P. aeruginosa</i>, as well as the possibility of using QS inhibitors (QSIs) and antibiotics in future therapeutic approaches for <i>P. aeruginosa</i>-associated infections.