Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
Taken together, these results support a role for astrocyte dysfunction in α-syn accumulation and DA neuronal loss following TLR2 activation in PD.
Authors
- Fiona Weiss
- Nicolas Dzamko (ORCID: https://orcid.org/0000-0002-9121-0294)
- YuHong Fu (ORCID: https://orcid.org/0000-0003-4539-2039)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Cédric Bardy (ORCID: https://orcid.org/0000-0001-8321-0852)
- Laura P. Hughes
Institutions
- The University of Sydney (AU)
- South Australian Health and Medical Research Institute (AU)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2024-12-16
- DOI
- https://doi.org/10.1186/s40035-024-00448-3
- Citations
- 11
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Sydney
- National Health and Medical Research Council
- Faculty of Medicine and Health, University of Sydney