Hypothalamic Hamartoma Cause of Precocious Puberty: About Two Cases

Hypothalamic hamartoma is a rare cause of central precocious puberty in children. The use of neuroimaging in central precocious puberty in girls is essential to detect an organic cause, however exceptional, namely hypothalamic hamartoma, Although the GnRH analogs are known to be effective therapy, there are few studies of the recovery of the pituitary-gonadal axis following long-term treatment. We report 2 cases of precocious puberty revealing the presence of a hypothalamic hamartoma, collated in the endocrinology-pediatrics department at the RABAT children's hospital, to obtain a better understanding of the clinical aspects, pathogenesis, and treatment of this entity.