CRP deposition in human abdominal aortic aneurysm is associated with transcriptome alterations toward aneurysmal pathogenesis: insights from in situ spatial whole transcriptomic analysis
CRP deposition was associated with significant transcriptomic changes in macrophages, lymphocytes, and vascular smooth muscle cells in AAA, suggesting its potential role in promoting pro-inflammatory and apoptotic processes, as well as contributing to the degradation of vascular structure and elasticity.
Authors
- Joon Seo Lim (ORCID: https://orcid.org/0000-0002-2738-5882)
- Se Jin Oh (ORCID: https://orcid.org/0000-0002-1516-5313)
- You Jung Ok (ORCID: https://orcid.org/0000-0003-0524-3979)
- Chong Jai Kim (ORCID: https://orcid.org/0000-0002-2844-9446)
- Jae Sung Choi (ORCID: https://orcid.org/0000-0001-5408-9029)
- Jiwon Koh (ORCID: https://orcid.org/0000-0002-7687-6477)
- Eun Na Kim (ORCID: https://orcid.org/0000-0003-2992-7881)
- Heeyoung Seok (ORCID: https://orcid.org/0000-0003-2699-9935)
- Jeong Mo Bae (ORCID: https://orcid.org/0000-0003-0462-3072)
- Chung‐Hyun Cho (ORCID: https://orcid.org/0000-0002-0585-713X)
- Ga-Hyeon Ryu
Institutions
- Ulsan College (KR)
- Seoul National University (KR)
- Seoul Metropolitan Government (KR)
- Asan Medical Center (KR)
- Seoul National University Hospital (KR)
- University of Ulsan (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1475051
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea