The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models
These results suggest that clobenpropit could be a promising new treatment for SLE, offering a targeted approach with potential advantages over current therapies.
Authors
- Vincent Rodeschini (ORCID: https://orcid.org/0000-0002-4758-5021)
- Darragh Duffy (ORCID: https://orcid.org/0000-0002-8875-2308)
- Stéphane Giorgiutti (ORCID: https://orcid.org/0000-0002-4791-9618)
- Jean‐Philippe Herbeuval (ORCID: https://orcid.org/0000-0001-8114-8012)
- Nassima Bekaddour
- Stéphanie Dupuy
- Sébastien Nisole (ORCID: https://orcid.org/0000-0001-9793-419X)
- Pauline Soulas‐Sprauel (ORCID: https://orcid.org/0000-0002-2058-4811)
- Vincent Gies (ORCID: https://orcid.org/0000-0002-8658-8604)
- Anne‐Sophie Korganow (ORCID: https://orcid.org/0000-0002-1664-6311)
- Birgit Caspar
- Nikaïa Smith (ORCID: https://orcid.org/0000-0002-0202-612X)
- Nicolas Leboulanger (ORCID: https://orcid.org/0000-0003-3466-6903)
- Séverine Grinberg (ORCID: https://orcid.org/0009-0005-6710-2006)
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Recherche en Infectiologie de Montpellier (FR)
- Laboratoire d'Informatique en Images et Systèmes d'Information (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1490593
- Citations
- 3
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Agence Nationale de la Recherche
- Karolinska Institutet
- HORIZON EUROPE Marie Sklodowska-Curie Actions