Optimizing tacrolimus therapeutic drug monitoring in Tunisian kidney transplant recipients: exploring the variability in bioavailability and the correlation between pharmacokinetic parameters
This study underscores the necessity for individualized therapeutic drug monitoring in Tunisian kidney transplant recipients due to the high variability in the Cp(0)/weight dosage ratio. The AUC0-12 h/Cp(0) ratio is proposed as a more consistent parameter for therapeutic drug monitoring, offering potential improvements in tacrolimus therapy management.
Authors
- Syrine Ben Hammamia (ORCID: https://orcid.org/0000-0001-6625-6648)
- Ghaith Aloui (ORCID: https://orcid.org/0009-0002-8580-6080)
- Emna Gaïes
- Mouna Daldoul (ORCID: https://orcid.org/0000-0001-6395-9049)
- Rim Charfi (ORCID: https://orcid.org/0000-0002-7714-3670)
- Riadh Daghfous
- Mohamed Zouari (ORCID: https://orcid.org/0000-0001-9491-816X)
- Mouna Ben Sassi (ORCID: https://orcid.org/0000-0002-7672-4684)
- Sameh Trabesli
- Hanene Eljeberi
Institutions
- Tunis El Manar University (TN)
Publication Details
- Journal
- Drug Metabolism and Personalized Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1515/dmpt-2024-0043
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00