Giant cell arteritis following SARS-CoV-2 infection
Giant cell arteritis (GCA) is a vasculitis characterised by arterial inflammation, with permanent vision loss being a feared complication. The association between GCA and viral infections is well-known, but there is limited data regarding its relationship to COVID-19. A man in his 80s with a recent history of COVID-19 developed sudden vision loss, persistent headaches and jaw claudication. Ophthalmological findings raised the suspicion of a GCA diagnosis, which was confirmed by temporal artery biopsy. Treatment with prednisone stabilised vision and resolved systemic symptoms. Reports suggest a potential temporal correlation between GCA onset and COVID-19 infection, warranting further investigation into potential mechanisms and clinical implications. This case supports an infectious trigger for GCA, which is a leading theory regarding its pathogenesis.
Authors
- Sepehr Fekrazad (ORCID: https://orcid.org/0000-0001-7302-6824)
- Jonathan Andrew Micieli (ORCID: https://orcid.org/0000-0003-4911-9152)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Kensington Health (CA)
Publication Details
- Journal
- BMJ Case Reports
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/bcr-2024-261988
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00