Giant cell arteritis following SARS-CoV-2 infection

Giant cell arteritis (GCA) is a vasculitis characterised by arterial inflammation, with permanent vision loss being a feared complication. The association between GCA and viral infections is well-known, but there is limited data regarding its relationship to COVID-19. A man in his 80s with a recent history of COVID-19 developed sudden vision loss, persistent headaches and jaw claudication. Ophthalmological findings raised the suspicion of a GCA diagnosis, which was confirmed by temporal artery biopsy. Treatment with prednisone stabilised vision and resolved systemic symptoms. Reports suggest a potential temporal correlation between GCA onset and COVID-19 infection, warranting further investigation into potential mechanisms and clinical implications. This case supports an infectious trigger for GCA, which is a leading theory regarding its pathogenesis.

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Publication Details

Journal
BMJ Case Reports
Published
2024-12-01
DOI
https://doi.org/10.1136/bcr-2024-261988
Primary Topic
Vasculitis and related conditions
Type
article
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article

Giant cell arteritis following SARS-CoV-2 infection

Sepehr Fekrazad, Jonathan Andrew Micieli
BMJ Case Reports
Vasculitis and related conditions
article

Giant cell arteritis following SARS-CoV-2 infection

Sepehr Fekrazad, Jonathan Andrew Micieli
article en

Abstract

Giant cell arteritis (GCA) is a vasculitis characterised by arterial inflammation, with permanent vision loss being a feared complication. The association between GCA and viral infections is well-known, but there is limited data regarding its relationship to COVID-19. A man in his 80s with a recent history of COVID-19 developed sudden vision loss, persistent headaches and jaw claudication. Ophthalmological findings raised the suspicion of a GCA diagnosis, which was confirmed by temporal artery biopsy. Treatment with prednisone stabilised vision and resolved systemic symptoms. Reports suggest a potential temporal correlation between GCA onset and COVID-19 infection, warranting further investigation into potential mechanisms and clinical implications. This case supports an infectious trigger for GCA, which is a leading theory regarding its pathogenesis.

BMJ Case ReportsVol. 17(12)
Massachusetts Eye and Ear Infirmary (US), St. Michael's Hospital (CA), University of Toronto (CA), Kensington Health (CA)
Good health and well-being
Openalex Percentile: Top 58%
Vasculitis and related conditions
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Giant cell arteritis following SARS-CoV-2 infection — Sepehr Fekrazad, Jonathan Andrew Micieli · BMJ Case Reports (2024) | TGRS Research Map | TGRS