Autophagy modulates tenogenic differentiation of cartilage-derived stem cells in response to mechanical tension via FGF signaling
Our findings provide insights into CDSC transplantation for achieving biological regeneration of tendon injuries, and demonstrate how modulation of autophagy in CDSCs can promote tenogenic differentiation in response to tensile stress both in vivo and in vitro.
Authors
- Chenhui Cai (ORCID: https://orcid.org/0000-0001-6919-2731)
- Yuan Xu (ORCID: https://orcid.org/0000-0001-5207-1730)
- H. Li
- Jie Li (ORCID: https://orcid.org/0000-0003-2343-1658)
- Wen Xia
- Yi Zhang (ORCID: https://orcid.org/0000-0003-0391-7159)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-3923-6999)
- Changqing Li (ORCID: https://orcid.org/0000-0002-0278-0798)
- Jiabin Liu
- Yuzhang Wu
- Rui Zuo (ORCID: https://orcid.org/0000-0002-3564-1356)
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Institute of Immunology (HR)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1093/stcltm/szae085
- Citations
- 1
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Army Medical University