Combined treatment gamma knife radiosurgery and immunotherapy in a patient with brain metastases from malignant melanoma

Melanoma is a complex disease with a high propensity for brain metastatic spread. Gamma Knife radiosurgery (GKRS) is a minimally invasive procedure to treat intracranial metastasis with a high rate of local tumor control. In this report, we describe the ongoing management of a patient with the development of brain metastases that required GKRS procedures for a total of 17 brain metastases receiving concurrent immunotherapy with pembrolizumab. The first imaging of the patient showed better local control after GKRS. Combined management with immunotherapy and GKRS for brain metastases resulted in extended survival while preserving neurological function and reducing adverse treatment effects in a patient with advanced metastatic brain melanoma.