Design and Fabrication of Orodispersible Strip of Antiallergic Drug

In present study, sodium alginate as film forming polymer and Sodium Starch Glycolate as a disintegrant with combination in different ratios could be promisingly used for the design of orodispersible strip of Montelukast sodium.Results obtained from F5 batch with acceptable in-vitro disintegration and in-vitro dissolution than other batches.Orodispersible strip of Montelukast sodium in strength of 10 mg was prepared by solvent casting method using sodium alginate, sodium starch glycolate, propylene glycol 400, sodium saccharine, menthol and Brilliant blue FCF.Compatibility study of Montelukast sodium was carried out with help of FTIR spectra.Retention of basic peaks of Montelukast sodium in FTIR spectra of physical mixture of API and excipient, concluding that there was no incompatibility with the selected excipients.The strips were characterized for drug content, thickness, weight variation, water absorption capacity, disintegration, in vitro drug release.