Bilayer Tablets in Drug Delivery: A Concept of Modified Release

The potential of Bilayer tablets as novel drug delivery system is a promising platform for successful combination therapy.Bilayer tablets are modified release system in which one layer serves as loading dose and the other layer serves as maintenance dose to enhance the bioavailability or to avoid the interaction between the incompatible substances by separating them physically.Several pharmaceutical companies are currently developing bi-layer tablets for a variety of reasons: patent extension, therapeutic, and marketing purposes.Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets.The goal of this review article is to discuss different approaches, criteria for immediate and sustained release dosage form, manufacturing techniques, advanced techniques, evaluations, and therapeutic applications of bilayer tablet technology.