EXPERIMENTAL EVALUATION OF THE COMPARATIVE EFFECTS OF PANASA (ARTOCARPUS HETEROPHYLLUS LAM.) PAKWA PHALA AND BEEJA MAJJA ON SPERMATOGENESIS IN WISTAR ALBINO RATS.

Ayurveda is a holistic medicinal system from India that emphasises the balance of mind, body, and spirit for health maintenance. It heavily relies on local flora, herbs, and natural remedies, focusing on personalised treat-ments. One significant plant in Ayurvedic medicine is Artocarpus heterophyllus Lam, commonly known as jackfruit or ‘Panasa’ in Sanskrit. This plant is widely utilised for its culinary and medicinal properties, including applications such as Brmhana, Mamsavardhaka, Balya, Sukrala, and Vrana Ropana. Jackfruit is rich in pro-teins, fats, iron, carbohydrates, minerals, calcium, thiamine, niacin, riboflavin, vitamin C, and vitamin A. Moreover, many classical texts have documented the Vrshya action of Panasa Pakwa Phala and Beeja Majja. This study aimed to conduct a comparative experimental evaluation of the Vrshya effects of Panasa Pakwa Phala and Beeja Majja on spermatogenesis. Objective: Comparative Experimental study to evaluate Spermato-genic activity of Pakwa Phala (Fruit) and Beeja Majja (Seed) of Panasa (Artocarpus heterophyllus Lam.).Materials and method: The collection of Artocarpus heterophyllus fruits and seeds was done from the natural habitat of the Udupi district and authenticated. The experimental study assessed the comparative sper-matogenic activity of Panasa Pakwa Phala and Beeja Majja upon internal administration. Result and Discus-sion: In the experimental study, rats given Panasa Pakwa Phala exhibited a significant increase in body weight, a non-significant increase in sperm count, sluggish motility, and a decrease in non-motile sperm. Notably, there was a substantial reduction in amorphous head sperm and a non-significant rise in hookless sperm. Conversely, rats treated with Panasa Beeja also showed increased body weight but had different results in sperm motility and morphology, with a significant decrease in normal sperm morphology. This activity profile indicates the presence of a spermatogenesis effect more in the test drug Panasa Pakwa Phala than in Panasa Beeja. Con-clusion: The experimental study demonstrated statistically significant results regarding the internal use of Panasa Pakwa Phala and Beeja Majja, showing positive effects on various parameters. The spermatogenesis effect is more important with the Panasa Pakwa Phala test drug than Panasa Beeja.