Fungal biomarkers in HIV-associated disseminated histoplasmosis: a multicenter diagnostic accuracy study on the Guiana shield
If BDG alone may rule out histoplasmosis when negative, GM alone, either positive or negative, showed the best performances for the diagnosis of histoplasmosis. Given the poorer performances of BDG and GM than Histoplasma antigen detection assays commercially available, they should be considered as an alternative in settings where Histoplasma antigen detection assays remain unavailable. However, this study essentially provides insights in the performances of fungal biomarkers in disseminated histoplasmosis and does not represent recommendations for best practices.
Authors
- Stephen Vreden (ORCID: https://orcid.org/0000-0003-3959-737X)
- Aurore Moussiegt
- Antoine Adenis (ORCID: https://orcid.org/0000-0003-4000-4981)
- Mathieu Nacher (ORCID: https://orcid.org/0000-0001-9397-3204)
- Marja Van Eer
- Beatriz L. Gómez (ORCID: https://orcid.org/0000-0002-6641-1924)
- Sigrid Mac Donald
- Marie‐Elisabeth Bougnoux (ORCID: https://orcid.org/0000-0003-4721-2740)
- Diego H. Cáceres (ORCID: https://orcid.org/0000-0001-8749-9809)
- Olivier Lortholary
- Tom Chiller
Institutions
- Centers for Disease Control and Prevention (US)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- University of French Guiana (GF)
- Anton de Kom University of Suriname (SR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Myologie (FR)
- Centre Hospitalier Andrée Rosemon (GF)
- Multi Electrical System (Suriname) (SR)
- Universidad del Rosario (CO)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.ijid.2024.107360
- Citations
- 1
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Merck
- Styrelsen för Internationellt Utvecklingssamarbete
- European Commission
- Institut National de la Santé et de la Recherche Médicale