Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study
This study demonstrates a progressive increase in insulin resistance and hyperinsulinemia in parallel to elevated BMI and hepatic steatosis prevalence, accompanied by declining circulating CEACAM1 levels. Cluster analysis further linked reduced insulin clearance to lower circulating CEACAM1 levels, suggesting its potential usefulness as a biomarker for metabolic disease progression.
Authors
- Rita S. Patarrão (ORCID: https://orcid.org/0000-0001-8701-2917)
- Verena Schmitt (ORCID: https://orcid.org/0000-0002-6951-6406)
- Maria João Meneses (ORCID: https://orcid.org/0000-0002-8236-5411)
- Rogério T. Ribeiro (ORCID: https://orcid.org/0000-0001-8840-7208)
- Hilda E. Ghadieh (ORCID: https://orcid.org/0000-0002-7983-2090)
- Carlos Penha‐Gonçalves (ORCID: https://orcid.org/0000-0001-7225-1907)
- Sérgio Duarte (ORCID: https://orcid.org/0000-0003-0471-2729)
- Maria Paula Macedo (ORCID: https://orcid.org/0000-0002-2549-0275)
- Bernhard B. Singer (ORCID: https://orcid.org/0000-0002-2213-6000)
- Amalia Gastaldelli (ORCID: https://orcid.org/0000-0003-2594-1651)
- João Filipe Raposo (ORCID: https://orcid.org/0000-0003-2589-7208)
- Sonia Michael Najjar (ORCID: https://orcid.org/0000-0001-6209-8902)
- Laura Manuela Robayo Herrera
Institutions
- University of Balamand (LB)
- University of Florida (US)
- Associacao Protectora dos Diabeticos de Portugal (PT)
- Istituto di Fisiologia Clinica (IT)
- Ohio University (US)
- National Research Council (IT)
- University of Duisburg-Essen (DE)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/eci.14344
- Citations
- 3
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Osteopathic Heritage Foundation
- Sociedade Portuguesa De Diabetologia
- European Commission
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Fundação para a Ciência e a Tecnologia