In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis
Cortical cell body loss in multiple sclerosis is most pronounced in cortical lesions and also present in normal-appearing cortex. Gradients of diffusion microstructural alterations moving outward from cortical lesions toward normal-appearing cortex highlight the potential of high-gradient diffusion MRI to identify both focal and diffuse cortical pathology.
Authors
- Samantha Noteboom (ORCID: https://orcid.org/0000-0003-4796-8636)
- Florence L. Chiang (ORCID: https://orcid.org/0000-0002-3405-5590)
- Eric C. Klawiter (ORCID: https://orcid.org/0000-0002-3429-2633)
- Martijn D. Steenwijk (ORCID: https://orcid.org/0000-0002-8346-9044)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Eva A. Krijnen (ORCID: https://orcid.org/0000-0002-3628-4127)
- Susie Y. Huang (ORCID: https://orcid.org/0000-0003-2950-7254)
- Hansol Lee (ORCID: https://orcid.org/0000-0003-2112-1197)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Amsterdam Neuroscience (NL)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1002/acn3.52237
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- Koning Boudewijnstichting
- National Institutes of Health