NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment
Our investigation revealed the pro-tumorigenic role of the NLRP3 inflammasome and its regulation of PD-L1 expression in EOC. Blockade of the NLRP3 inflammasome led to reduced PD-L1 expression, fewer immunosuppressive cells, and suppressed tumor growth. These findings suggest that targeting the NLRP3 inflammasome-PD-L1 axis could be a novel treatment approach for ovarian cancer.
Authors
- Jingtong Du
- Kexin Chang (ORCID: https://orcid.org/0009-0001-0316-1809)
- Yiming Liu (ORCID: https://orcid.org/0000-0002-9698-3691)
- Wenjing Pan (ORCID: https://orcid.org/0009-0008-6331-7837)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8920-1172)
- Wenhua Tan
- Zhaoyang Jia (ORCID: https://orcid.org/0000-0001-8814-9691)
- Xibo Zhao (ORCID: https://orcid.org/0000-0002-7103-5273)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/itt.s495564
- Citations
- 10
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.34