Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort
Risk-based eligibility using PLCO<sub>m2012</sub> successfully classified most eventual lung cancer cases in the high-risk, screened group. Prediction models generally underestimated risk in this socioeconomically deprived cohort, irrespective of screening status. The effect of screening on increasing the probability of lung cancer diagnosis should be considered when interpreting measures of prediction model performance.
Authors
- Matthew Sperrin (ORCID: https://orcid.org/0000-0002-5351-9960)
- Patrick Goodley (ORCID: https://orcid.org/0000-0002-5729-2548)
- Richard Booton (ORCID: https://orcid.org/0000-0003-4512-2899)
- Haval Balata (ORCID: https://orcid.org/0000-0002-8596-9376)
- Hilary A. Robbins (ORCID: https://orcid.org/0000-0001-6041-6866)
- Philip Crosbie (ORCID: https://orcid.org/0000-0001-8941-4813)
Institutions
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Centre international de recherche sur le cancer (FR)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/bmjonc-2024-000560
- Citations
- 3
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- National Institute for Health and Care Research
- Siemens Healthineers
- Manchester Biomedical Research Centre
- National Cancer Institute