Research Progress on the Anti-Breast Cancer Effect and Mechanism of Oxymatrine

Oxymatrine (OMT), an alkaloid derived from Sophora flavescens, possesses a diverse array of pharmacological activities, encompassing anti-inflammatory, antiviral, antitumor, and immune regulatory properties. In recent times, significant strides have been made in investigating the efficacy of OMT against breast cancer. OMT exerts its anticancer influence through various mechanisms, including inhibition of tumor cell proliferation, suppression of tumor cell invasion and migration, induction of tumor cell apoptosis, and disruption of the cell cycle. This article systematically reviews the underlying mechanisms of OMT in breast cancer therapy by conducting a comprehensive search across multiple databases, such as CNKI, Wanfang, and PubMed, utilizing keywords like "OMT," "breast cancer," "pharmacology," and "pharmacokinetics," as well as incorporating both Chinese and English terms for "OMT," "triple-negative breast cancer," and "breast cancer." The objective is to delve into the potential applications of OMT in breast cancer treatment and furnish a valuable reference for future clinical investigations exploring the utilization of OMT in this field.