Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells
Inhalation of smoke from burn pits during military deployment is associated with several adverse pulmonary outcomes. We exposed human airway epithelial cells to smoke condensates from burn pit waste materials. Single and repeated exposure to condensates triggered unique and common responses in terms of gene expression that were sustained through the recovery phase. Source material and combustion condition influenced the outcome. Intensified response in female donor cells indicated a determining role of biological sex. The observations indicate a lasting impact of burn pit smoke exposure on epithelial gene expression, potentially contributing to disease pathogenesis.
Authors
- M. Ian Gilmour (ORCID: https://orcid.org/0000-0002-3070-6704)
- Keith L Rogers
- Stephanie A. Brocke (ORCID: https://orcid.org/0000-0002-1916-799X)
- Ilona Jaspers (ORCID: https://orcid.org/0000-0001-8728-0305)
- Scott H. Randell (ORCID: https://orcid.org/0000-0001-5351-2841)
- Samuel C Gallant
- Adam M. Speen (ORCID: https://orcid.org/0000-0002-3153-8378)
- Yong Ho Kim (ORCID: https://orcid.org/0000-0001-7527-0134)
- Arunava Ghosh (ORCID: https://orcid.org/0000-0001-9550-1366)
Institutions
- University of North Carolina at Chapel Hill (US)
- Environmental Protection Agency (US)
- Lung Institute (US)
- National Center for Environmental Assessment (EPA) (US)
Publication Details
- Journal
- Toxicological Sciences
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1093/toxsci/kfae161
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- U.S. Environmental Protection Agency
- Office of Research and Development