P056 Comparison of Breas Vivo 45 LS and ResMed Lumis ventilators in three simulated disease conditions

Abstract Background Ventilator performance has been shown to vary across conditions, ventilator type, and in common scenarios such as mask leak. Aim: This study sought to compare the performance of a Breas Medical AB (Mölnlycke, Sweden) Vivo 45 LS™ and ResMed (San Diego, CA, USA) Lumis™ ventilator. Methods Pressure, flow and volume waveforms were sampled for each ventilator at analogous settings, under three simulated clinical conditions using an ASL5000™ (Ingmar Medical, Pittsburgh, PA, USA) respiratory simulator: (A) Kyphoscoliosis (very low compliance), (B) Obesity Hypoventilation (low compliance), (C) Motor Neuron Disease (normal compliance, low muscle strength). Results Qualitative visual comparisons of representative breaths revealed similar delivered inspiratory and expiratory pressures. Flow profiles and volumes differed, with the Lumis showing shorter breath durations (range 0.1 - 0.5s) and correspondingly lower volumes compared to Vivo 45LS. Peak flows varied among the conditions, with the Vivo 45LS higher in condition A (27 vs 31 L/min) similar in condition B (45 L/min), but lower in condition C (27 vs 24 L/min). Mean inspiratory pressures were similar except in condition A, where the Vivo 45LS was lower by around 4 cmH2O. Expiratory volumes and peak pressures were comparable across both devices. Conclusions Comparative analysis of the Breas Vivo 45LS and ResMed Lumis ventilators under simulated clinical conditions highlights differences in breath duration, delivered volumes, and peak flow for analogous settings. Future research should better quantify and explore the impact of these performance variations between ventilators on clinical outcomes including ventilation efficacy, patient-ventilator synchrony, user comfort, and usage.