Molecular Study of the Impact of LDHA Gene and MIR-383 Interaction on the Progression of Ovarian Cancer in Iraqi Female Patients

Ovarian cancer is a major cause of death from gynecological malignancies globally, often detected at late stages due to non-specific symptoms, hence its nickname "silent killer."It arises from various ovarian tissues, mainly classified into epithelial, germ cell, and stromal tumors, with serous carcinoma as the most common form.Significant risk factors include genetic predispositions, such as BRCA1/BRCA2 mutations, reproductive history, and lifestyle factors, while socioeconomic differences markedly affect prognosis and treatment results.Recent studies underscore the significance of lactate dehydrogenase A (LDHA), a crucial enzyme in glycolysis; it promotes cell growth and metabolic changes that lead to the development of cancer.It is closely associated with hypoxiainducible factor 1-alpha (HIF-1).Furthermore, microRNAs, especially miR-383, are recognized as potential anti-tumor agents by targeting oncogenes like LDHA, influencing cancer cell activities including invasion, cell death, and chemotherapy resistance.The study aims to verify the inverse correlation between miR-383 and LDHA levels in ovarian cancer, highlighting their potential as therapeutic targets and markers for improving treatment strategies