O077 Nocturia as a Marker for Cardiovascular Risk in Obstructive Sleep Apnoea

Abstract Background Obstructive Sleep Apnoea (OSA) is highly prevalent and is associated with cardiovascular (CV) risk. Factors beyond AHI alone appear to influence this risk. Clinical biomarkers of cardiovascular risk in OSA are needed to assist clinicians in making treatment decisions. Nocturia is a commonly reported symptom in OSA. This study aims to assess the association between nocturia and cardiovascular risk. Methods Patients with OSA (AHI>5/h) were selected from the Sydney Sleep Biobank. Patients aged 30-74yrs who had adequate data to calculate an office-based Framingham Risk Score (FRS) and who had answered the relevant question relating to nocturia in Pittsburgh Sleep Quality Index. The sample was divided into groups based on FRS or pre-existing cardiovascular disease. We then compared the frequency of significant nocturia, defined as ≥3 times per week disrupting sleep. Progress to Date 605 patients (69% male, mean [±sd] age 52.9 ± 13.6 years, body mass index (32.8 ± 8.6) were included. 55% reported significant nocturia. FRS was low in 16.9%, moderate in 36.4% and high in 35.0% and pre-existing cardiovascular disease was reported in 11.7% and nocturia was reported by 56%, 71%, 81%, and 83% of those groups respectively. Nocturia was associated with increased cardiovascular risk (χ² = 21.1, df 2 with p<0.001). Intended Outcome and Impact Patient reported nocturia was associated with increased CVD risk. This exploratory study is limited by a lack of detailed reporting on nocturia, but suggests clinical utility of nocturia for assessment of CVD risk. Further analysis is planned regarding confounding factors.