P045 Association between childhood cystic fibrosis lung disease and adolescent sleep and mental health

Abstract Background Sleep disruption imposes deleterious physiological and psychological effects. We aimed to describe the relationship between school age respiratory health on adolescent sleep disturbance and mental health symptoms in people living with cystic fibrosis. Methods We conducted a prospective longitudinal study of adolescents aged 10 to 18 years from October 2020 to June 2024. Sleep was evaluated via serial measures of the pediatric daytime sleepiness scale (PDSS) and sleep disturbance scale for children (SDSC), while mental health was assessed with the Patient Health Questionnaire-9 (PHQ-9) for depression and Generalised Anxiety Disorder-7 (GAD-7) for anxiety. Respiratory health was measured alongside, using FEV1 percent predicted and multiple breath washout (MBW). Childhood chest CT scan were previously collected via DEFEND CF (Biomarkers to define the treatment end-points for pulmonary exacerbations in CF) and scored using the Perth-Rotterdam Annotated Grid Morphometric Analysis for CF (PRAGMA-CF). Linear regression was used to estimate mean difference in sleep and mental health change per school age CT bronchiectasis score. Results 64 adolescents were studied. 56% of participants experienced sleep disturbance symptoms, 45% for mental health symptoms, with no significant association between childhood bronchiectasis score and adolescent PDSS, SDSC scores. Adolescent anxiety and depression scores also did not significantly correlate with childhood bronchiectasis scores. Conclusion While childhood bronchiectasis score did not predict adolescent sleep or mental health, sleep disturbance and symptoms of anxiety and depression were prevalent in the cohort. The need for ongoing monitoring and support in these areas remains crucial for adolescents with cystic fibrosis.